Codon-by-codon modulation of translational speed and accuracy via mRNA folding.
Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage.However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff.Here we provide genomic evidence in budding yeast and mouse embryonic stem cells that the efficiency-accuracy conflict is alleviated by slowing down the Bongs e